The association between bone age advancement and insulin in prepubertal children with obesity

Results The study population included 49 (47.6%) males and 54 (52.4%) females with a mean age of 7.6 ± 1.6 years. The advanced bone age group defined as BA-CA>1 year (n=53) had significantly higher HOMA-IR, fasting insulin levels and lower quantitative insulin sensitivity check index (QUICKI). Also, BA-CA was significantly correlated with fasting insulin (r=0.315, P<0.001), HOMA-IR (r=0.288, P<0.001), and QUICKI (r=-0.353, P<0.001). In multiple regression analysis, fasting insulin was identified as significant independent predictors for BA-CA.